Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ETS2 |
| Gene Name: | ETS2 |
| Protein Full Name: | Protein C-ets-2 |
| Alias: | C-ets-2 protein; ETS2; v-ets erythroblastosis virus E26 oncogene 2 |
| Mass (Da): | 53001 |
| Number AA: | 469 |
| UniProt ID: | P15036 |
| Locus ID: | 2114 |
| COSMIC ID: | ETS2 |
| Gene location on chromosome: | 21q22.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20337 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | ETS2 is involved in regulation of cell proliferation and differentiationg of certain cell types, stem cell development, cell senesence and death. Expression in transformed cells allows for growth in absence of serum, anchorage-independent growth and tumorigenesis. |