Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | JUP |
| Gene Name: | JUP |
| Protein Full Name: | Junction plakoglobin |
| Alias: | Catenin, gamma; CTNNG; Desmoplakin III; DP3; DPIII; Gamma-catenin; PDGB; PKGB; PLAK; Plakoglobin |
| Mass (Da): | 81745 |
| Number AA: | 745 |
| UniProt ID: | P14923 |
| Locus ID: | 3728 |
| COSMIC ID: | JUP |
| Gene location on chromosome: | 17q21.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19968 |
| Percent of cancer specimens with mutations: | 0.67 |
| Normal role description: | Also known as gamma-catenin. Part of the cadherin-catenin complex. Interacts with RTKs and also the tumour suppresor APC. Shares homology with beta-catenin and is theorized to have similar proto-oncogene qualities |