Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CCNB1 |
| Gene Name: | CCNB1 |
| Protein Full Name: | G2/mitotic-specific cyclin-B1 |
| Alias: | CCN2; CCN-2; CCNB; CCNB1-RS1; CYCB; CYCB1 |
| Mass (Da): | 48337 |
| Number AA: | 433 |
| UniProt ID: | P14635 |
| Locus ID: | 891 |
| COSMIC ID: | CCNB1 |
| Gene location on chromosome: | 5q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR (no mutations found) |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.27 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | Cyclin B1 is a nuclear cyclin-dependent protein kinase activator. It is essential for the control of the cell cycle at the G2/M (mitosis) transition. It complexes with CDC2 to form the maturation-promoting factor. An alternate transcript, one that is constitutively expressed, stems from an alternate transcription initiation site. Strong cytoplasmic antibody staining in a small fraction of malignant cells was found in most malignancies and overexpression has been associated with many cancers, suggesting an oncogenic role. |