Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CDH1 |
| Gene Name: | CDH1 |
| Protein Full Name: | Cadherin-1 |
| Alias: | CADH1; Cadherin 1, type 1, E-cadherin (epithelial); Cadherin 1, type 1, E-cadherin (epithelial) (ECAD); Cadherin-1; CAM 120,80; CAM 120/80; CD324; CDHE; E-cadherin; Epithelial-cadherin; UVO; Uvomorulin |
| Mass (Da): | 97456 |
| Number AA: | 882 |
| UniProt ID: | P12830 |
| Locus ID: | 999 |
| COSMIC ID: | CDH1 |
| Gene location on chromosome: | 16q22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 23826 |
| Percent of cancer specimens with mutations: | 2.74 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with point mutations, complex mutations, insertions and deletions over entire protein length. |
| Mutations observed as inherited: | familial gastric carcinoma. Non-hereditary: invasive cancers. |
| Gene undergoes hypermethylation: | Bladder, breast, colon and gastric cancers. |
| Normal role description: | Receptor for cell-cell adhesion. It plays major roles in cell recognition, cell sorting, and a critical supporter intercellular adhesion. Loss of expression correlates with invasiveness and metastatic potential of cancers. |