Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PCNA |
| Gene Name: | PCNA |
| Protein Full Name: | Proliferating cell nuclear antigen |
| Alias: | Cyclin |
| Mass (Da): | 28769 |
| Number AA: | 261 |
| UniProt ID: | P12004 |
| Locus ID: | 5111 |
| COSMIC ID: | PCNA |
| Gene location on chromosome: | 20p13 |
| Cancer protein type: | N/A |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.18 |
| Normal role description: | This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. NON-ANOTATED GENE |