Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Pim1 |
| Gene Name: | PIM1 |
| Protein Full Name: | Proto-oncogene serine/threonine-protein kinase pim |
| Alias: | EC 2.7.11.1 |
| Mass (Da): | 45412 |
| Number AA: | 404 |
| UniProt ID: | P11309 |
| Locus ID: | 5292 |
| COSMIC ID: | PIM1 |
| Gene location on chromosome: | 6p21.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 21110 |
| Percent of cancer specimens with mutations: | 0.43 |
| Deregulated in translocations: | t(3;6)(q27;p21.2) diffuse large B-cell lymphoma (DLCL) --> BCL6 / PIM1 |
| Deregulated by viral insertion: | Moloney murine leukemia virus (MoMLV) - Mouse |
| Normal role description: | PIM1 is a protein-serine/threonine kinase. It is involved in signal transduction of hematopoeic cells. Promotes cell proliferation and oncogenesis by stabilizing and potentiating the MYC signalling pathway. PM1 mediates survival signalling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Also promotes cell survival by phosphorylating and inhibiting MAP3K activity. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B. |