Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AR |
| Gene Name: | AR |
| Protein Full Name: | Androgen receptor |
| Alias: | AIS; ANDR; DHTR; Dihydrotestosterone receptor; HUMARA; Kennedy disease; NR3C4; SBMA; SMAX1; testicular feminization |
| Mass (Da): | 98989 |
| Number AA: | 919 |
| UniProt ID: | P10275 |
| Locus ID: | 367 |
| COSMIC ID: | AR |
| Gene location on chromosome: | Xq12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20233 |
| Percent of cancer specimens with mutations: | 1.23 |
| Commonly recorded point mutations: | T878A (10) |
| Normal role description: | Mutations in AR gene transform prostate androgen signalling from paracrine to autocrine function. This results in increased proliferation and tumorogenesis. Genes involved in AR pathway upregulation by increasing AR signal promiscuity, decreasing AR destruction, and increasing signal amplification are also implicated in AR-related oncogenesis. |