Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FGF2 |
| Gene Name: | FGF2 |
| Protein Full Name: | Heparin-binding growth factor 2 |
| Alias: | Basic fibroblast growth factor |
| Mass (Da): | 17254 |
| Number AA: | 288 |
| UniProt ID: | P09038 |
| Locus ID: | 2247 |
| COSMIC ID: | FGF2 |
| Gene location on chromosome: | 4q27 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.17 |
| Normal role description: | FGF2 belongs to the fibroblast growth factor family. It is involved in many cellular processes, promotes cell proliferation, migration, survival and regulates embryonic development. It has a double function in apoptosis. May induce apoptosis through reduction of the antiapoptotic protein BCL-2. FGF2 expression is increased in a great variety of tumors (>90% in malignant gliomas) and generally associated with tumour progression, relapse and poor prognosis. |