Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ROS1 |
| Gene Name: | ROS1 |
| Protein Full Name: | Proto-oncogene tyrosine-protein kinase ROS |
| Alias: | C-ros oncogene 1 , receptor tyrosine kinase; C-ros-1; EC 2.7.10.1; KROS; MCF3; Proto-oncogene tyrosine-protein kinase ROS; ROS1; V-ros UR2 sarcoma virus oncogene homolog 1 (avian); V-ros UR2 sarcoma virus oncogene homologue 1 (avian) |
| Mass (Da): | 263915 |
| Number AA: | 2347 |
| UniProt ID: | P08922; Q5H8Y3 |
| Locus ID: | 6098 |
| COSMIC ID: | ROS1 |
| Gene location on chromosome: | 6q22 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20711 |
| Percent of cancer specimens with mutations: | 2.51 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many point mutations across entire protein, but no complex mutations, insertions or deletions. |
| Deregulated in translocations: | Fusion partners include FIG and GOPC. |
| Transduced into viral genome: | UR2 virus - Chicken |
| Normal role description: | ROS1 is a receptor-tyrosine kinase that is activated upon binding an unidentified ligand. Suggested to activate several downstream signalling pathways in cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signalling pathway. Highly expressed in several human cancers. |