Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RhoC |
| Gene Name: | RHOC |
| Protein Full Name: | Rho-related GTP-binding protein RhoC |
| Alias: | ARH9; ARHC; H9; Ras gene family, member C; Transforming protein RhoC |
| Mass (Da): | 22006 |
| Number AA: | 193 |
| UniProt ID: | P08134 |
| Locus ID: | 389 |
| COSMIC ID: | RHOC |
| Gene location on chromosome: | 1p13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.15 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | RHOC is a monomeric G protein that plays a role in the assembly of focal adhesions and actin stress fibres and promotes cell motility. Overexpression has been associated with tumour cell proliferation and invasion while a dominant-negative Rho inhibits tumour invasion, both of which suggests that Rho is important in metastasis. It may also be involved in inducing angiogenic factors in mammary epithelial cells and vascularizing solid tumors. |