Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | eIF4E |
| Gene Name: | EIF4E |
| Protein Full Name: | Eukaryotic translation initiation factor 4E |
| Alias: | eIF-4F 25 kDa subunit;mRNA cap-binding protein |
| Mass (Da): | 25097 |
| Number AA: | 217 |
| UniProt ID: | P06730 |
| Locus ID: | 1977 |
| COSMIC ID: | EIF4E |
| Gene location on chromosome: | 4q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20337 |
| Percent of cancer specimens with mutations: | 0.19 |
| Found in amplified chromosomal regions in human cancers: | HNSCC and breast carcinomas |
| Normal role description: | EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of protein synthesis. The region containing the EIF4E locus on chromosome 4q has been implicated in autism, and the gene is over-expressed in several epithelial cancers |