Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TFAP2A |
| Gene Name: | TFAP2A |
| Protein Full Name: | Transcription factor AP-2 alpha (Activating enhanc |
| Alias: | Transcription factor AP-2 alpha |
| Mass (Da): | 48303 |
| Number AA: | 439 |
| UniProt ID: | P05549 |
| Locus ID: | 7020 |
| COSMIC ID: | TFAP2A |
| Gene location on chromosome: | 6p24.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | TFAP2A is a transcriptional regulator. It regulates transcriptions of genes involved in development, embryogenesis, differentiation, cell growth, apoptosis and tumorigenesis. KIT, CDKN1A and ERBB2 are genes that are activated. MYC, CLCP1 and MUC18 are genes that are repressed. Reduced expression in melanoma, breast cancer, prostate cancer, ovarian cancer and gliomas have been associated with angiogensis, invasion, metastasis and poorer prognosis. |