Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TFF1 |
| Gene Name: | TFF1 |
| Protein Full Name: | Trefoil factor 1 |
| Alias: | Breast cancer estrogen-inducible protein;PNR-2;Polypeptide P1.A;Protein pS2 |
| Mass (Da): | 9150 |
| Number AA: | 84 |
| UniProt ID: | P04155 |
| Locus ID: | 7031 |
| COSMIC ID: | TFF1 |
| Gene location on chromosome: | 21q22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.11 |
| Normal role description: | TFF1 is expressed on normal gastrointestinal mucosal cells. The normal physiological role of TFF1 is unclear but may be related to mucosal integrity and innate immunity. This protein expression is lost in gastic tumors. Conversely, TFF1 is strongly expressed in breast cancer cells but absent from normal breast tissue. TFF1 is estrogen-dependent in the breast cancer system. Given that specific functional details of TFF1 are known, it is difficult to speculate on its function in oncogenesis. |