Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BUB1B |
| Gene Name: | BUB1B |
| Protein Full Name: | Mitotic checkpoint serine/threonine-protein kinase |
| Alias: | BUB1 budding uninhibited by benzimidazoles 1 homologue beta (yeast); EC 2.7.11.1; HBUBR1; Kinase BubR1; MAD3/BUB1-related protein kinase |
| Mass (Da): | 119545 |
| Number AA: | 1050 |
| UniProt ID: | O60566 |
| Locus ID: | 701 |
| COSMIC ID: | BUB1B |
| Gene location on chromosome: | 15q15 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 1483 |
| Percent of cancer specimens with mutations: | 0.26972353338 |
| Normal role description: | BUB1B is a protein-serine/threonine kinase. It is an essential component of mitotic checkpoint. It prevents progression of anaphase until all the sister chomatids are connected to spindles by binding to CDC20 to anaphase promoting complex/cycolsome thus inhibiting it. It is also involved in localization of CENPE, a kinetochore motor that performs kinetochore functions. Other functions include suppression of centrosome amplification, negative regulation of PLK1 in intephase and trigger apoptosis in polyploid cells. |