Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BUB1 |
| Gene Name: | BUB1 |
| Protein Full Name: | Mitotic checkpoint serine/threonine-protein kinase |
| Alias: | BUB1A; BUB1L; Budding uninhibited by benzimidazoles 1; EC 2.7.11.1; HBUB1; MBUB1; Mitotic checkpoint BUB1 |
| Mass (Da): | 122375 |
| Number AA: | 1085 |
| UniProt ID: | O43683 |
| Locus ID: | 699 |
| COSMIC ID: | BUB1 |
| Gene location on chromosome: | 2q13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20621 |
| Percent of cancer specimens with mutations: | 0.7 |
| Normal role description: | BUB1 is a protein-serine/threonine kinase and is a checkpoint protein that regulates mitotic spindle formation. It is a key protein in the formation of centromeres. It is thus the key regulator of metaphase-to-anaphase progression. Loss of function of the BUB1 gene results in abnormal propagation of genetic material during mitosis. |