Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PROM1 |
| Gene Name: | PROM1 |
| Protein Full Name: | Prominin-1 |
| Alias: | AC133; CD133; hematopoietic stem cell antigen; prominin-like 1; PROML1 |
| Mass (Da): | 97202 |
| Number AA: | 865 |
| UniProt ID: | O43490 |
| Locus ID: | 8842 |
| COSMIC ID: | PROM1 |
| Gene location on chromosome: | 4p15.32 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19783 |
| Percent of cancer specimens with mutations: | 0.73 |
| Normal role description: | PROM1 is a regulator in stem cells by preventing differentiation. It is also involved in membrane organization of apical surface of epitheial cells, regulates retinal development. It can play a role in MAPK and AKT signalling. |