Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AURKA |
| Gene Name: | AURKA |
| Protein Full Name: | Serine/threonine-protein kinase 6 |
| Alias: | AIK; ARK1; AurA; Aurora kinase A; Aurora,IPL1-related kinase 1; Aurora/IPL1-related kinase 1; Aurora-1; Aurora-A; Aurora-family kinase 1; Aurora-related kinase 1; AYK1; Breast-tumor-amplified kinase; BTAK; EC 2.7.11.1; IAK1; Ipl1- and aurora-related kinase 1; Kinase AurA; Serine/threonine kinase 15; Serine/threonine kinase 6; Serine/threonine kinase Ayk1; STK15; STK6; STK7 |
| Mass (Da): | 45809 |
| Number AA: | 403 |
| UniProt ID: | O14965 |
| Locus ID: | 6790 |
| COSMIC ID: | AURKA |
| Gene location on chromosome: | 20q13.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 1574 |
| Percent of cancer specimens with mutations: | 0.44472681067 |
| Found in amplified chromosomal regions in human cancers: | Amplification event detected in breast cancers (coexpressed with BRCA1 and BRCA2 mutants), pancreatice ductal adenocarcinomas, ovarian cancers, bladder cancer, colon cancer, and multiple myelomas. |
| Normal role description: | AURKA is a serine/threonine kinase and a key regulator of mitotic cell division. It is involved in regulating microtubule formation and the assembly of the mitotic spindle responsible for chromosome segragation during mitosis. AURKA activity is cell cycle dependent with the greatest activity occuring during mitosis. The overexpression of AURKA has been well documented in many malignant cancers including breast, ovarian, colon, prostate and neuroblastomas. Overexpression of AURKA appears to override checkpoints in cell cycle progression leading to increased cell division and proliferation. |