Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC9A3R1 |
| Gene Name: | SLC9A3R1 |
| Protein Full Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
| Alias: | EBP50; Ezrin-radixin-moesin binding phosphoprotein-50; NHERF1; NHERF-1; Similar to solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulatory factor 1; Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1; Solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulatory factor 1 |
| Mass (Da): | 38868 |
| Number AA: | 358 |
| UniProt ID: | O14745 |
| Locus ID: | 9368 |
| COSMIC ID: | SLC9A3R1 |
| Gene location on chromosome: | 17q25.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19745 |
| Percent of cancer specimens with mutations: | 0.14 |
| Normal role description: | Connects plasma membrane proteins with members of the ezrin/moesin/radixin family and links them to the actin cytoskeleton. It is neccessary for recycling of ADRB2 after internalization and phosphorylation and inhibition of SLC9A3. Induced by estrogen. Depending on its localization (membrane vs cytoplasm) it may either act as a tumour suppressor or as an oncogene. |