Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRAF5 |
| Gene Name: | TRAF5 |
| Protein Full Name: | TNF receptor-associated factor 5 |
| Alias: | RING finger protein 84 |
| Mass (Da): | 64406 |
| Number AA: | 557 |
| UniProt ID: | O00463 |
| Locus ID: | 7188 |
| COSMIC ID: | TRAF5 |
| Gene location on chromosome: | 1q32.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20152 |
| Percent of cancer specimens with mutations: | 0.44 |
| Normal role description: | TRAF5 meditates TNF binding to receptor and propagates TNF signalling. Although role in oncogenesis has not been well established, it can be speculated that defects in this protein will lead to downregulated apoptosis signalling and tumour survival. |