Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAB27A |
| Gene Name: | RAB27A |
| Protein Full Name: | Ras-related protein Rab-27A |
| Alias: | GS2; GTP-binding protein Ram; HsT18676; RAB27; RAB27A, member RAS oncogene family; RAM |
| Mass (Da): | 24850 |
| Number AA: | 221 |
| UniProt ID: | A2RU94 |
| Locus ID: | 5873 |
| COSMIC ID: | RAB27A |
| Gene location on chromosome: | 15q15-q21.1 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.2 |
| Commentary on involvement of protein in cancer: | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. |